Henderson is best known as a designer-hoodie, black Ray-Bans, expensive sneakers-wearing famous comedian with a 'hard-life-lessons man-of-the-people' thing working for him. He is a popular comedian who recently beat testicular cancer. It is revealed that he has an appetite for underage girls. He tricks them into believing they have a friendship and trusting him before drugging them and sexually assaulting them, taking pictures of them while they are unconscious and hiding the pictures in a secret compartment in his hidden sex room.
Joe finds out about his activities through his neighbor, Delilah, who was a victim of Henderson. Joe intercepts Henderson's attempted assault on Delilah's fifteen year old sister Ellie. He intends to get Henderson to confess, but accidentally kills him after he attempts to escape and fight Joe.
"This happened to you too, didn't it? That's why you're doing this? You hate yourself so you're trying to destroy me? We're the same."
"You're trying to be a hero? Is that what you think this is? You feel like a piece of shit so you're trying to be a hero. Ruining my life is not going to save you from your demons, alright? What we went through stays. No amount of sex or drugs or religion or surviving fucking ball cancer, that's not gonna save you okay, nothing can."
- Henderson is the only one of Joe's murders to be a complete accident.