She was born in Cottonwood, Arizona and raised in Murrieta, California and she has two sisters. She attended Vista Murrieta High School.
After appearing in the 2003 film Dickie Roberts: Former Child Star, she became established for her role on the daytime soap opera All My Children as Colby Chandler, who she portrayed from 2006 to 2008. She also played Elizabeth "E" Dodd in The Master.
She and Kate Bosworth teamed up to co-create Ambyr Childers Jewelry, a new line of delicate pieces that mixes Childers's Native American heritage with Bosworth's "essential cool-girl vibe".
In 2018, she starred in Lifetime's television adaptation of You as Candace Stone, which premiered on September 9, 2018. On December 3, 2018, it was announced that You would move to Netflix as a "Netflix Original" title, ahead of the premiere of the second season. On February 1, 2019, it was announced by Deadline, that she was promoted to a series regular role, ahead of the premiere of the second season.
She married film producer Randall Emmett in 2009. The couple had a daughter in 2010 and a second daughter in 2013. He filed for legal separation in April 2015, and the couple divorced in December 2017.
(08/05/2020) Ambyr Childers Jewelry, Jewelry business to empower women, founded and run by Ambyr Childers in California. Ambyr Childers started her namesake jewelry line with a desire to create timeless pieces that inspire and empower those who wear them. As a token of beauty and a celebration of women and friendship, her signature design, the Rise Totem, was born. Encompassing the heart and soul of the brand, it is meant to serve as a daily reminder of our inner strength and connection with the feminine force. Ambyr Childers' jewelry is thoughtfully designed and crafted with the hope and intention of being cherished forever. Her mission is to delicately capture the magic of ancestry, infuse meaning and symbolism into luxurious yet practical jewelry, and embolden the wearer to Rise and Shine. Check it out at https://www.ambyrchilders.com/